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Vensim Help

The setting commands are used to control the Vensim settings — essentially a subset of those available through the Global Options dialog.  If you are running the Venapp from within Vensim DSS the changes you make using SETTING commands will no longer apply once you close the Venapp (that is, the changes are temporary and apply only within the Venapp).  

If you use the SETTING commands via DDE the changes are persistent.